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Basics
Name | Chathurani Ranathunge |
Label | Bioinformatics Scientist |
caranathunge86@gmail.com | |
Url | https://caranathunge.github.io |
Work
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2024 - Present Houston, TX
Lead Bioinformatics Scientist
University of Houston
Project: Gene fusions as candidates for cancer vaccines
- Collaborated with multidisciplinary teams of molecular biologists, immunologists, and clinicians to design mRNA‐based vaccines for specific breast cancer subtypes and blood cancers.
- Developed an automated pipeline with R and Python that reduced processing time for identifying gene fusion candidates for vaccines from hours to seconds, achieving over a 99% improvement in efficiency
- Built a reproducible, scalable, and efficient pipeline to streamline in-silico validation of gene fusions (Bash)reducing analysis time by 80%
- Developed reproducible bioinformatics pipelines to analyze epigenetic data from ChIP-Seq experiments.
- Delivered reports and presentations to external collaborators translating complex bioinformatics findings into actionable insights for experimental design and clinical research.
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2021 - 2024 Norfolk, VA
Senior Research Associate, Computational Biology
Eastern Virginia Medical School
Project: Digital patient
- Collaborated with cross-functional teams, which included mass spectrometrists, computer scientists, and clinicians to analyze and interpret proteomics and clinical data to identify early detection biomarkers for prostate cancer.
- Spearheaded a project to develop the R package, promor, to streamline proteomics data analysis and machine learning based predictive modeling, resulting in 2 peer reviewed publications and 3 presentations
- Created reproducible reports using RMarkdown and Quarto to effectively communicate results from statistical data analysis to both technical and non-technical stakeholders.
- Utilized git/GitHub for version control to ensure collaboration and code integrity within the teams
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2018 - 2021 Gainesville, FL
Postdoctoral Associate
University of Florida
Project: Eco-system dynamics in the rapidly changing Arctic
- Collaborated with multi‑disciplinary research teams from 2 universities to study rapidly changing Arctic ecosystems.
- Collected and processed Arctic moss samples for DNA isolation and constructed NGS libraries for Illumina sequencing to support genomic research on Arctic ecosystems.
- Developed and maintained NGS data pipelines for automated processing of genomics data (RAD-seq and target capture sequencing), facilitating downstream population genetic, phylogenetic, and statistical analysis of Arctic mosses.
- Provided training and guidance to 3 junior researchers/analysts, promoting their professional growth.
- Presented scientific reports and presentations to internal and external collaborators translating research findings into actionable insights for ecological studies.
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2013 - 2018 Starkville, MS
Graduate Teaching/Research Assistant
Mississippi State University
Project: The functional and adaptive role of short tandem repeats (STRs)
- Developed qPCR assays for short tandem repeat (STR) containing genes and performed molecular tests and procedures to investigate the role of STRs in gene expression regulation in common sunflower
- Conducted statistical, differential expression, and enrichment analysis on bulk RNA-seq, qPCR, and PCR data identifying over 400 STRs involved in gene expression regulation in sunflowers, contributing to significant discoveries in plant biology and functional tandem repeats
- Trained and mentored 7 junior researchers promoting their professional development
- Published 5 research articles (first author) and presented 12 research talks and 3 posters.
- Taught 4 lower level and 3 upper-level biology laboratory courses.
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2011 - 2013 Makandura, Sri Lanka
Assistant Lecturer
Wayamba University of Sri Lanka
Research and teaching
- Supervised 2 undergraduate research projects resulting in 2 peer-reviewed publications.
- Taught 2 lower level and 4 upper-level laboratory courses, including Genetic Engineering.
Education
Awards
- 2022
Best Poster - Computational Mass Spectrometry
International Society for Computational Biology
- 2019
Emerging Scholar
East Carolina University - Office for Equity and Diversity
- 2018
Young Scientist Excellence Award
Mid‑South Computational Biology and Bioinformatics Society
- 2018
Outstanding Graduate Research Assistant of the Year
Department of Biological Sciences, Mississippi State University
- 2017
W. D. Hamilton Award - Honorable Mention
Society for the Study of Evolution
- 2017
Outstanding Oral Presentation- Botany
Botanical Society of America (Southeastern section)
- 2017
Outstanding Oral Presentation - Cell and Molecular Biology
Association of Southeastern Biologists
- 2017
Outstanding Graduate Teaching Assistant of the Year
Department of Biological Sciences, Mississippi State University
- 2016
Oral Presentation - Second Place
Mid‑South Computational Biology and Bioinformatics Society
- 2016
Graduate Student Research Award
Botanical Society of America
- 2012
Dr. Dharmawansa Senadhira Award for Best Performance in Biotechnology
Wayamba university of Sri Lanka
Certificates
Computational Biology Certificate | ||
Institute for Genomics, Biocomputing, and Biotechnology, Mississippi State University | 2018 |
Skills
Programming languages | |
Python | |
R | |
Perl | |
Bash |
Data Analysis & Bioinformatics Tools | |
High Performance Computing Clusters (HPC) | |
SLURM | |
conda | |
Bioconductor | |
R package development (testthat, roxygen, pkgdown) |
Version Control | |
git | |
GitHub |
Data Visualization | |
ggplot2 | |
matplotlib |
Analysis & Reporting | |
RMarkdown | |
Quarto | |
Jupyter Notebook | |
LaTeX |
Omics Disciplines | |
Genomics (RADSeq, Target capture sequencing) | |
Proteomics (DIA) | |
Transcriptomics (bulk RNA-seq) | |
ChIP-seq |
NGS Data Analysis | |
Genome/Transcriptome Assembly (Bowtie, BWA, Trinity, samtools) | |
Differential Expression (DESeq2, edgeR) | |
Enrichment Analysis (blast2GO) | |
Databases (NCBI, GTEx, TCGA,COSMIC) | |
ChIP-seq Analysis (MACS2, deepTools) | |
Variant analysis (IGV) | |
Tandem Repeats (RepeatSeq, Tandem Repeat Finder) |
Molecular Techniques | |
PCR | |
qPCR | |
DNA and RNA isolation | |
NGS library preparation |
Languages
Sinhalese | |
Native speaker |
English | |
Fluent |