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Basics

Name Chathurani Ranathunge
Label Bioinformatics Scientist
Email caranathunge86@gmail.com
Url https://caranathunge.github.io

Work

  • 2024 - Present

    Houston, TX

    Lead Bioinformatics Scientist
    University of Houston
    Project: Gene fusions as candidates for cancer vaccines
    • Collaborated with multidisciplinary teams of molecular biologists, immunologists, and clinicians to design mRNA‐based vaccines for specific breast cancer subtypes and blood cancers.
    • Developed an automated pipeline with R and Python that reduced processing time for identifying gene fusion candidates for vaccines from hours to seconds, achieving over a 99% improvement in efficiency
    • Built a reproducible, scalable, and efficient pipeline to streamline in-silico validation of gene fusions (Bash)reducing analysis time by 80%
    • Developed reproducible bioinformatics pipelines to analyze epigenetic data from ChIP-Seq experiments.
    • Delivered reports and presentations to external collaborators translating complex bioinformatics findings into actionable insights for experimental design and clinical research.
  • 2021 - 2024

    Norfolk, VA

    Senior Research Associate, Computational Biology
    Eastern Virginia Medical School
    Project: Digital patient
    • Collaborated with cross-functional teams, which included mass spectrometrists, computer scientists, and clinicians to analyze and interpret proteomics and clinical data to identify early detection biomarkers for prostate cancer.
    • Spearheaded a project to develop the R package, promor, to streamline proteomics data analysis and machine learning based predictive modeling, resulting in 2 peer reviewed publications and 3 presentations
    • Created reproducible reports using RMarkdown and Quarto to effectively communicate results from statistical data analysis to both technical and non-technical stakeholders.
    • Utilized git/GitHub for version control to ensure collaboration and code integrity within the teams
  • 2018 - 2021

    Gainesville, FL

    Postdoctoral Associate
    University of Florida
    Project: Eco-system dynamics in the rapidly changing Arctic
    • Collaborated with multi‑disciplinary research teams from 2 universities to study rapidly changing Arctic ecosystems.
    • Collected and processed Arctic moss samples for DNA isolation and constructed NGS libraries for Illumina sequencing to support genomic research on Arctic ecosystems.
    • Developed and maintained NGS data pipelines for automated processing of genomics data (RAD-seq and target capture sequencing), facilitating downstream population genetic, phylogenetic, and statistical analysis of Arctic mosses.
    • Provided training and guidance to 3 junior researchers/analysts, promoting their professional growth.
    • Presented scientific reports and presentations to internal and external collaborators translating research findings into actionable insights for ecological studies.
  • 2013 - 2018

    Starkville, MS

    Graduate Teaching/Research Assistant
    Mississippi State University
    Project: The functional and adaptive role of short tandem repeats (STRs)
    • Developed qPCR assays for short tandem repeat (STR) containing genes and performed molecular tests and procedures to investigate the role of STRs in gene expression regulation in common sunflower
    • Conducted statistical, differential expression, and enrichment analysis on bulk RNA-seq, qPCR, and PCR data identifying over 400 STRs involved in gene expression regulation in sunflowers, contributing to significant discoveries in plant biology and functional tandem repeats
    • Trained and mentored 7 junior researchers promoting their professional development
    • Published 5 research articles (first author) and presented 12 research talks and 3 posters.
    • Taught 4 lower level and 3 upper-level biology laboratory courses.
  • 2011 - 2013

    Makandura, Sri Lanka

    Assistant Lecturer
    Wayamba University of Sri Lanka
    Research and teaching
    • Supervised 2 undergraduate research projects resulting in 2 peer-reviewed publications.
    • Taught 2 lower level and 4 upper-level laboratory courses, including Genetic Engineering.

Education

  • 2013 - 2018

    Mississippi, USA

    PhD
    Mississippi State University
    Biological Sciences
  • 2007 - 2011

    Makandura, Sri Lanka

    BSc
    Wayamba University of Sri Lanka
    Biotechnology

Awards

Certificates

Computational Biology Certificate
Institute for Genomics, Biocomputing, and Biotechnology, Mississippi State University 2018

Skills

Programming languages
Python
R
Perl
Bash
Data Analysis & Bioinformatics Tools
High Performance Computing Clusters (HPC)
SLURM
conda
Bioconductor
R package development (testthat, roxygen, pkgdown)
Version Control
git
GitHub
Data Visualization
ggplot2
matplotlib
Analysis & Reporting
RMarkdown
Quarto
Jupyter Notebook
LaTeX
Omics Disciplines
Genomics (RADSeq, Target capture sequencing)
Proteomics (DIA)
Transcriptomics (bulk RNA-seq)
ChIP-seq
NGS Data Analysis
Genome/Transcriptome Assembly (Bowtie, BWA, Trinity, samtools)
Differential Expression (DESeq2, edgeR)
Enrichment Analysis (blast2GO)
Databases (NCBI, GTEx, TCGA,COSMIC)
ChIP-seq Analysis (MACS2, deepTools)
Variant analysis (IGV)
Tandem Repeats (RepeatSeq, Tandem Repeat Finder)
Molecular Techniques
PCR
qPCR
DNA and RNA isolation
NGS library preparation

Languages

Sinhalese
Native speaker
English
Fluent